Gene name:
Map3k8 (Cot;Tpl2) ;
Protein name:
Mitogen-activated protein kinase kinase kinase 8 ;
Alternative:
Proto-oncogene c-Cot ;Cancer Osaka thyroid oncogene ;Tumor progression locus 2 (TPL-2) ;Serine/threonine-protein kinase cot ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms a ternary complex with NFKB1 and TNIP2.
Function:
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MEYMSTGSDE | KEEIDLLIKH | LNVSEVIDIM | ENLYASEEPG | VYEPSLMTMY |
100:
PDSNQNEERS | ESLLRSGQEV | PWLSSVRYGT | VEDLLAFANH | VSNMTKHFYG |
150:
RRPQECGILL | NMVISPQNGR | YQIDSDVLLV | PWKLTYRNIG | SGFVPRGAFG |
200:
KVYLAQDMKT | KKRMACKLIP | IDQFKPSDVE | IQACFRHENI | AELYGAVLWG |
250:
DTVHLFMEAG | EGGSVLEKLE | SCGPMREFEI | IWVTKHILKG | LDFLHSKKVI |
300:
HHDIKPSNIV | FMSTKAVLVD | FGLSVKMTED | VYLPKDLRGT | EIYMSPEVIL |
350:
CRGHSTKADI | YSLGATLIHM | QTGTPPWVKR | YPRSAYPSYL | YIIHKQAPPL |
400:
EDIAGDCSPG | MRELIEAALE | RNPNHRPKAA | DLLKHEALNP | PREDQPRCQS |
450:
LDSALFERKR | LLSRKELQLP | ENIADSSCTG | STEESEVLRR | QRSLYIDLGA |
467:
LAGYFNIVRG | PPTLEYG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 8
Protein for Mouse Mitogen-activated protein kinase kinase kinase 8
Protein for Mouse Mitogen-activated protein kinase kinase kinase 8
Protein for Mouse Mitogen-activated protein kinase kinase kinase 8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 X CBA .
tissue :
Thymus .
2.
"TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway."
Dumitru C.D.
,
Ceci J.D.
,
Tsatsanis C.
,
Kontoyiannis D.
,
Stamatakis K.
,
Lin J.H.
,
Patriotis C.
,
Jenkins N.A.
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Copeland N.G.
,
Kollias G.
,
Tsichlis P.N.
Cell103:1071-1083(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CD40 AND TRAF6
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NFKB1;TISSUE SPECIFICITY
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
"Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."
Watford W.T.
,
Hissong B.D.
,
Durant L.R.
,
Yamane H.
,
Muul L.M.
,
Kanno Y.
,
Tato C.M.
,
Ramos H.L.
,
Berger A.E.
,
Mielke L.
,
Pesu M.
,
Solomon B.
,
Frucht D.M.
,
Paul W.E.
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Sher A.
,
Jankovic D.
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Tsichlis P.N.
,
O'Shea J.J.
J. Exp. Med.205:2803-2812(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION;DISRUPTION PHENOTYPE
7.
"Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis."
Jager J.
,
Gremeaux T.
,
Gonzalez T.
,
Bonnafous S.
,
Debard C.
,
Laville M.
,
Vidal H.
,
Tran A.
,
Gual P.
,
Le Marchand-Brustel Y.
,
Cormont M.
,
Tanti J.F.
Diabetes59:61-70(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
8.
"TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production."
McNab F.W.
,
Ewbank J.
,
Rajsbaum R.
,
Stavropoulos E.
,
Martirosyan A.
,
Redford P.S.
,
Wu X.
,
Graham C.M.
,
Saraiva M.
,
Tsichlis P.
,
Chaussabel D.
,
Ley S.C.
,
O'Garra A.
J. Immunol.191:1732-1743(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE